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Charles B Simone Selected Research

Protons (Proton)

6/2022Proton Therapy in the Management of Hepatocellular Carcinoma.
6/2022Proton Therapy in the Management of Luminal Gastrointestinal Cancers: Esophagus, Stomach, and Anorectum.
6/2022Proton Therapy in the Management of Pancreatic Cancer.
3/2022Phantosmia Among Pediatric, Adolescent, and Young Adult Patients Receiving Proton Beam Therapy.
1/2022A Universal Range Shifter and Range Compensator Can Enable Proton Pencil Beam Scanning Single-Energy Bragg Peak FLASH-RT Treatment Using Current Commercially Available Proton Systems.
1/2022Chemoradiation with Hypofractionated Proton Therapy in Stage II-III Non-Small Cell Lung Cancer: A Proton Collaborative Group Phase 2 Trial.
11/2021A Novel Proton Pencil Beam Scanning FLASH RT Delivery Method Enables Optimal OAR Sparing and Ultra-High Dose Rate Delivery: A Comprehensive Dosimetry Study for Lung Tumors.
7/2021Quantitative Assessment of 3D Dose Rate for Proton Pencil Beam Scanning FLASH Radiotherapy and Its Application for Lung Hypofractionation Treatment Planning.
1/2021Using patient-specific bolus for pencil beam scanning proton treatment of periorbital disease.
1/2021FLASH Radiotherapy Using Single-Energy Proton PBS Transmission Beams for Hypofractionation Liver Cancer: Dose and Dose Rate Quantification.
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Charles B Simone Research Topics

Disease

125Neoplasms (Cancer)
06/2022 - 01/2007
86Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
06/2022 - 02/2012
35Lung Neoplasms (Lung Cancer)
01/2022 - 01/2012
23Malignant Mesothelioma
01/2021 - 12/2014
15Neoplasm Metastasis (Metastasis)
05/2021 - 10/2013
14Small Cell Lung Carcinoma (Small Cell Lung Cancer)
05/2021 - 09/2014
12COVID-19
07/2022 - 01/2020
11Pain (Aches)
10/2019 - 09/2008
10Radiation Pneumonitis
10/2021 - 09/2014
10Prostatic Neoplasms (Prostate Cancer)
01/2021 - 10/2002
9Mesothelioma
03/2021 - 02/2013
9Pneumonia (Pneumonitis)
01/2021 - 01/2016
6Esophageal Neoplasms (Esophageal Cancer)
06/2022 - 08/2016
6Head and Neck Neoplasms (Head and Neck Cancer)
01/2022 - 12/2011
5Carcinoma (Carcinomatosis)
01/2021 - 10/2010
4Hepatocellular Carcinoma (Hepatoma)
06/2022 - 10/2019
4Circulating Neoplastic Cells
01/2022 - 01/2015
4Breast Neoplasms (Breast Cancer)
10/2021 - 01/2019
4Adenocarcinoma
01/2021 - 02/2019
4Brain Neoplasms (Brain Tumor)
01/2021 - 11/2015
4Sarcoma (Soft Tissue Sarcoma)
10/2020 - 07/2016
4Thymoma (Thymic Carcinoma)
07/2019 - 03/2016
4Dyspnea (Shortness of Breath)
01/2019 - 10/2013
4Nasopharyngeal Neoplasms (Cancer of the Nasopharynx)
02/2018 - 11/2017
3Infections
04/2022 - 01/2020
3Hypertension (High Blood Pressure)
04/2022 - 01/2019
3Adenocarcinoma of Lung
10/2021 - 01/2014
3Esophagitis
10/2021 - 01/2017
3Nausea
03/2021 - 01/2017
2Gastrointestinal Neoplasms (Gastrointestinal Cancer)
06/2022 - 08/2016
2Liver Neoplasms (Liver Cancer)
04/2022 - 01/2021
2Vomiting
03/2021 - 01/2017
2Pathologic Complete Response
08/2020 - 01/2018
2Renal Cell Carcinoma (Grawitz Tumor)
07/2019 - 10/2017
2Urinary Bladder Neoplasms (Bladder Cancer)
01/2019 - 11/2018
2Inflammation (Inflammations)
01/2019 - 01/2018
2Lymphoma (Lymphomas)
01/2019 - 01/2017
2Melanoma (Melanoma, Malignant)
11/2018 - 01/2016
2Cardiovascular Diseases (Cardiovascular Disease)
04/2018 - 08/2017
2Cardiotoxicity
01/2018 - 10/2017
2Hemoptysis
12/2014 - 10/2013
2Cough
07/2014 - 10/2013
1Thrombosis (Thrombus)
06/2022
1Liver Failure
06/2022
1Stomach Neoplasms (Stomach Cancer)
06/2022
1Pancreatic Neoplasms (Pancreatic Cancer)
06/2022
1Staphylococcal Infections
06/2022
1Thromboembolism
04/2022
1Stroke (Strokes)
04/2022
1Myocardial Infarction
04/2022

Drug/Important Bio-Agent (IBA)

46Protons (Proton)IBA
06/2022 - 12/2011
141-phenyl-3,3-dimethyltriazene (PDT)IBA
01/2020 - 02/2013
5Biomarkers (Surrogate Marker)IBA
01/2021 - 01/2016
4durvalumabIBA
01/2022 - 01/2020
3Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
07/2022 - 01/2019
3Proteins (Proteins, Gene)FDA Link
06/2022 - 01/2019
3Biological ProductsIBA
10/2021 - 01/2016
3Immune Checkpoint InhibitorsIBA
05/2021 - 04/2017
3Telomerase (Telomerase Reverse Transcriptase)IBA
01/2020 - 01/2015
3Pharmaceutical PreparationsIBA
03/2019 - 12/2014
3Analgesics (Analgesic Drugs)IBA
02/2012 - 09/2008
2Adrenal Cortex Hormones (Corticosteroids)IBA
04/2022 - 07/2020
2RNA (Ribonucleic Acid)IBA
10/2021 - 07/2020
2pembrolizumabIBA
01/2020 - 11/2018
2ErbB Receptors (EGF Receptor)IBA
01/2020 - 01/2015
2Dihematoporphyrin Ether (Porfimer Sodium)FDA Link
01/2019 - 01/2017
2NivolumabIBA
11/2018 - 07/2018
2Pemetrexed (MTA)FDA Link
03/2017 - 12/2016
2Singlet OxygenIBA
01/2017 - 12/2014
2Messenger RNA (mRNA)IBA
01/2016 - 01/2013
2AntioxidantsIBA
03/2007 - 01/2007
1Phenobarbital (Luminal)FDA Link
06/2022
1NLR ProteinsIBA
06/2022
1AnticoagulantsIBA
04/2022
1Immunosuppressive Agents (Immunosuppressants)IBA
04/2022
1Yttrium-90IBA
04/2022
1YttriumIBA
04/2022

Therapy/Procedure

153Radiotherapy
06/2022 - 09/2011
54Therapeutics
07/2022 - 09/2008
50Proton Therapy
06/2022 - 01/2012
41Drug Therapy (Chemotherapy)
01/2022 - 02/2012
15Photochemotherapy (Photodynamic Therapy)
01/2020 - 02/2012
14Chemoradiotherapy
03/2022 - 01/2017
11Immunotherapy
05/2021 - 10/2015
9Re-Irradiation
07/2020 - 01/2017
8Palliative Care (Palliative Therapy)
08/2017 - 01/2012
7Cranial Irradiation
01/2021 - 11/2015
5Pneumonectomy (Lung Volume Reduction)
11/2020 - 09/2017
4Neoadjuvant Therapy
01/2021 - 07/2017
4Intensity-Modulated Radiotherapy (Radiotherapy, Intensity Modulated)
12/2018 - 12/2011
3Prostatectomy (Retropubic Prostatectomy)
02/2022 - 01/2021
3Pain Management
02/2012 - 09/2008
2Craniospinal Irradiation
03/2022 - 09/2011
2Adjuvant Chemotherapy
08/2021 - 07/2019
2Treatment Delay
01/2021 - 04/2020
2Induction Chemotherapy
01/2019 - 01/2018
2Heavy Ion Radiotherapy
12/2018 - 01/2017
2Drug Tapering
01/2017 - 11/2016
2Complementary Therapies (Alternative Medicine)
02/2012 - 09/2008
1Artificial Respiration (Mechanical Ventilation)
04/2022